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KMID : 0356619940090020108
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Journal of Korean Society of Endocrinology
1994 Volume.9 No. 2 p.108 ~ p.114
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Changes in Insulin Sensitivity and insulin, Secretory Function in Hyperthyroid Patients
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이대호
정민영/장연진/박상선/최은진/강호철/조재현/이태희
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Abstract
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impairement of glucose metabolism is frequently associated in hyperthyroidism. The present study was performed to determine the effect of the thyroid hormone excess on insulin sensitivity and on insulin secretory function in vivo. Ten newly
diagnosed
hyperthyroid patients an fifteen healthy control subjects were subjected to frequently sampled intravenous glucose tolerance tests (FSIGT) after an overnight fast. Insulin sensitivity, represented by the insulin sensitivity index (S1), was
assessed
by
minimal model analysis of FSIGT data. Insulin secretion was measured by the total area under the insulin curve after glucose load.
@ES The results were as follows.
1) The Kg values, which represent glucose tolerance, were not different between the hyperthyroid patients and the normals (2.2±0.3vs 2.5±0.3%/min, P>0.05).
2)S1 was significantly decreases in the hyperthyroid patients in comparison to the normals(7.5±1.4 vs. 2.6±0.3×10-4 min-1/uU/ml, p0.05).
3) The basal insulin concentration was higher in the hyperthyroid patients than in the normals (8.3±2.4 vs. 4.6±0.4 uU/ml, p=0.07). In addition, the insulin secretory response to a glucose load was increased in the hyperthyroid patients as
evidence by
the peak plasma insulin level (168.2±30.4 vs. 89.2±13.9uU/ml, p<0.05) and by the total area under the insulin curve (2641.1±443.2 vs. 1696.7±204.3 min, uU/ml, p<0.05).
There results clearly demonstrated that insulin sensitivity was impaired in these newly diagnosed hyperthyroid patients. However, glucose tolerance was maintained by the increased insulin secretion (J Kor Soc Endocrinol 9:108~14, 1994)
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KEYWORD
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